The directors and members of the Intelligent Clinical Care Center (IC3) have published over 1,500 articles in peer-reviewed, scholarly journals. These include journals such as Nature Reviews Nephrology, Scientific Reports, JAMA Internal Medicine, JAMA Network Open, The Lancet Digital Health, Medical Image Analysis, BMJ Health & Care Informatics, PLOS ONE, Kidney International, and Surgery.
Listed below are recent publications from some of the IC3 member labs. For more information on publications by specific IC3 members or labs, please refer to the IC3 Members page or the IC3 Labs page.
PRISMAP
IC3 co-director Azra Bihorac, associate directors of research Tyler Loftus and Tezcan Ozrazgat Baslanti, and assistant director of clinical AI Benjamin Shickel are all part of the Precision and Intelligent Systems in Medicine Research Partnership (PRISMAP) in the UF College of Medicine.
Melatonin enhances NK cell function in aged mice by increasing T-bet expression via the JAK3-STAT5 signaling pathway
Natural killer (NK) cells are crucial innate immune cells that provide defense against viruses and tumors. However, aging is associated with alterations in NK cell composition and compromised cell functions.…
The Acute Kidney Intervention and Pharmacotherapy (AKIP) List: Standardized List of Medications That Are Renally Eliminated and Nephrotoxic in the Acutely Ill
The objective of this project was to develop a standardized list of renally eliminated and potentially nephrotoxic drugs that will help inform initiatives to improve medication safety. Several available lists…
Community-engaged artificial intelligence research: A scoping review
The degree to which artificial intelligence healthcare research is informed by data and stakeholders from community settings has not been previously described. As communities are the principal location of healthcare…
Severe trauma leads to sustained muscle loss, induced frailty, and distinct temporal changes in myokine and chemokine profiles of older patients
CONCLUSIONS: Severe blunt trauma in older adults is associated with increased incidence of induced sarcopenia and reversible induced frailty. Despite muscle wasting, functional decline is transient, with a return to…
i-Heal Lab
IC3 co-director Parisa Rashidi leads the Intelligent Health Systems (i-Heal) Lab in the UF Herbert Wertheim College of Engineering.
Community-engaged artificial intelligence research: A scoping review
The degree to which artificial intelligence healthcare research is informed by data and stakeholders from community settings has not been previously described. As communities are the principal location of healthcare…
APRICOT-Mamba: Acuity Prediction in Intensive Care Unit (ICU): Development and Validation of a Stability, Transitions, and Life-Sustaining Therapies Prediction Model
On average, more than 5 million patients are admitted to intensive care units (ICUs) in the US, with mortality rates ranging from 10 to 29%. The acuity state of patients…
Developing a fair and interpretable representation of the clock drawing test for mitigating low education and racial bias
The clock drawing test (CDT) is a neuropsychological assessment tool to screen an individual’s cognitive ability. In this study, we developed a Fair and Interpretable Representation of Clock drawing test…
Prediction of Robotic Anastomosis Competency Evaluation (RACE) metrics during vesico-urethral anastomosis using electroencephalography, eye-tracking, and machine learning
Residents learn the vesico-urethral anastomosis (VUA), a key step in robot-assisted radical prostatectomy (RARP), early in their training. VUA assessment and training significantly impact patient outcomes and have high educational…
CMI Lab
IC3 associate director of research Pinaki Sarder leads the Computational Microscopy Imaging (CMI) Lab in the UF College of Medicine.
Urine complement proteins are associated with kidney disease progression of type 2 diabetes in Korean and American cohorts
CONCLUSIONS: Urinary proteomic profiling confirms the association between the complement pathway and rapid DKD progression in two independent cohorts. These results suggest a need to further investigate complement pathway inhibition…
PKR activation-induced mitochondrial dysfunction in HIV-transgenic mice with nephropathy
HIV disease remains prevalent in the USA and chronic kidney disease remains a major cause of morbidity in HIV-1-positive patients. Host double-stranded RNA (dsRNA)-activated protein kinase (PKR) is a sensor…
Investigating quantitative histological characteristics in renal pathology using HistoLens
HistoLens is an open-source graphical user interface developed using MATLAB AppDesigner for visual and quantitative analysis of histological datasets. HistoLens enables users to interrogate sets of digitally annotated whole slide…
<em>FUSION</em>: A web-based application for in-depth exploration of multi-omics data with brightfield histology
Spatial -OMICS technologies facilitate the interrogation of molecular profiles in the context of the underlying histopathology and tissue microenvironment. Paired analysis of histopathology and molecular data can provide pathologists with…
SMILE Lab
IC3 associate director of education Ruogu Fang leads the Smart Medical Informatics Learning and Evaluation (SMILE) Lab in the UF Herbert Wertheim College of Engineering.
BrainFounder: Towards Brain Foundation Models for Neuroimage Analysis
The burgeoning field of brain health research increasingly leverages artificial intelligence (AI) to interpret and analyze neurological data. This study introduces a novel approach towards the creation of medical foundation…
BrainSegFounder: Towards 3D foundation models for neuroimage segmentation
The burgeoning field of brain health research increasingly leverages artificial intelligence (AI) to analyze and interpret neuroimaging data. Medical foundation models have shown promise of superior performance with better sample…
Morphological profiling for drug discovery in the era of deep learning
Morphological profiling is a valuable tool in phenotypic drug discovery. The advent of high-throughput automated imaging has enabled the capturing of a wide range of morphological features of cells or…
Analysis and Visualization of Single-Cell Sequencing Data with Scanpy and MetaCell: A Tutorial
The emergence and development of single-cell RNA sequencing (scRNA-seq) techniques enable researchers to perform large-scale analysis of the transcriptomic profiling at cell-specific resolution. Unsupervised clustering of scRNA-seq data is central…