The directors and members of the Intelligent Clinical Care Center (IC3) have published over 1,500 articles in peer-reviewed, scholarly journals. These include journals such as Nature Reviews Nephrology, Scientific Reports, JAMA Internal Medicine, JAMA Network Open, The Lancet Digital Health, Medical Image Analysis, BMJ Health & Care Informatics, PLOS ONE, Kidney International, and Surgery.
Listed below are recent publications from some of the IC3 member labs. For more information on publications by specific IC3 members or labs, please refer to the IC3 Members page or the IC3 Labs page.
PRISMAP
IC3 co-director Azra Bihorac, associate directors of research Tyler Loftus and Tezcan Ozrazgat Baslanti, and assistant director of clinical AI Benjamin Shickel are all part of the Precision and Intelligent Systems in Medicine Research Partnership (PRISMAP) in the UF College of Medicine.
Unique lymphocyte transcriptomic profiles in septic patients with chronic critical illness
INTRODUCTION: Despite continued improvement in post-sepsis survival, long term morbidity and mortality remain high. Chronic critical illness (CCI), defined as persistent inflammation and organ injury requiring prolonged intensive care, is…
CIS-UNet: Multi-class segmentation of the aorta in computed tomography angiography via context-aware shifted window self-attention
Advancements in medical imaging and endovascular grafting have facilitated minimally invasive treatments for aortic diseases. Accurate 3D segmentation of the aorta and its branches is crucial for interventions, as inaccurate…
i-Heal Lab
IC3 co-director Parisa Rashidi leads the Intelligent Health Systems (i-Heal) Lab in the UF Herbert Wertheim College of Engineering.
Community-engaged artificial intelligence research: A scoping review
The degree to which artificial intelligence healthcare research is informed by data and stakeholders from community settings has not been previously described. As communities are the principal location of healthcare…
APRICOT-Mamba: Acuity Prediction in Intensive Care Unit (ICU): Development and Validation of a Stability, Transitions, and Life-Sustaining Therapies Prediction Model
On average, more than 5 million patients are admitted to intensive care units (ICUs) in the US, with mortality rates ranging from 10 to 29%. The acuity state of patients…
Developing a fair and interpretable representation of the clock drawing test for mitigating low education and racial bias
The clock drawing test (CDT) is a neuropsychological assessment tool to screen an individual’s cognitive ability. In this study, we developed a Fair and Interpretable Representation of Clock drawing test…
Prediction of Robotic Anastomosis Competency Evaluation (RACE) metrics during vesico-urethral anastomosis using electroencephalography, eye-tracking, and machine learning
Residents learn the vesico-urethral anastomosis (VUA), a key step in robot-assisted radical prostatectomy (RARP), early in their training. VUA assessment and training significantly impact patient outcomes and have high educational…
CMI Lab
IC3 associate director of research Pinaki Sarder leads the Computational Microscopy Imaging (CMI) Lab in the UF College of Medicine.
A <em>MEF2C</em> transcription factor network regulates proliferation of glomerular endothelial cells in diabetic kidney disease
The maintenance of a healthy epithelial-endothelial juxtaposition requires cross-talk within glomerular cellular niches. We sought to understand the spatially-anchored regulation and transition of endothelial and mesangial cells from health to…
Integration of spatial multiplexed protein imaging and transcriptomics in the human kidney tracks the regenerative potential timeline of proximal tubules
The organizational principles of nephronal segments are based on longstanding anatomical and physiological attributes that are closely linked to the homeostatic functions of the kidney. Novel molecular approaches have recently…
Urine complement proteins are associated with kidney disease progression of type 2 diabetes in Korean and American cohorts
CONCLUSIONS: Urinary proteomic profiling confirms the association between the complement pathway and rapid DKD progression in two independent cohorts. These results suggest a need to further investigate complement pathway inhibition…
PKR activation-induced mitochondrial dysfunction in HIV-transgenic mice with nephropathy
HIV disease remains prevalent in the USA and chronic kidney disease remains a major cause of morbidity in HIV-1-positive patients. Host double-stranded RNA (dsRNA)-activated protein kinase (PKR) is a sensor…
SMILE Lab
IC3 associate director of education Ruogu Fang leads the Smart Medical Informatics Learning and Evaluation (SMILE) Lab in the UF Herbert Wertheim College of Engineering.
Disagreement on foundational principles of biological aging
To gain insight into how researchers of aging perceive the process they study, we conducted a survey among experts in the field. While highlighting some common features of aging, the…
Phylogenetic-informed graph deep learning to classify dynamic transmission clusters in infectious disease epidemics
MOTIVATION: In the midst of an outbreak, identification of groups of individuals that represent risk for transmission of the pathogen under investigation is critical to public health efforts. Dynamic transmission…
Machine learning-optimized non-invasive brain stimulation and treatment response classification for major depression
CONCLUSION: These findings support our previously developed precision-dosing method for a new application in psychiatry by optimizing the statistical likelihood of tDCS treatment response in MDD.
BrainSegFounder: Towards 3D Foundation Models for Neuroimage Segmentation
The burgeoning field of brain health research increasingly leverages artificial intelligence (AI) to interpret and analyze neurological data. This study introduces a novel approach towards the creation of medical foundation…